Links & publications

screening of new anti-cancer agents

Balvers RK, Kleijn A, Kloezeman JJ, French P, Kremer A, Van de Bent MJ, Dirven CMF, Leenstra S, Lamfers MLM.
Serum-free culture success of glial tumors is related to specific molecular profiles and expression of extracellular matrix-associated gene modules.
Neuro-Oncology 2013 (in press)

Chou TC, Talalay P.
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.
Adv Enzyme Regul. 1984;22:27-55.

Duffy MJ, O’Donovan N, Crown J.
Use of molecular markers for predicting therapy response in cancer patients.
Cancer Treat Rev 2011;37:151-9.

Gasparini G, Longo R.
The paradigm of personalized therapy in oncology.
Expert Opin Ther Targets 2012;16 Suppl 1:S7-16.

Gravendeel, L.A., et al.,
Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology.
Cancer Res, 2009. 69(23): p. 9065-72.

Lee, J., et al.,
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.
Cancer Cell, 2006. 9(5): p. 391-403.

Li, A., et al.,
Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas.
Mol Cancer Res, 2008. 6(1): p. 21-30.

Pollard, S.M., et al.,
Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens.
Cell Stem Cell, 2009. 4(6): p. 568-80.

Verhaak, R.G., et al.,
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.
Cancer Cell, 2010. 17(1): p. 98-110